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PC/BPA 研究进展

《Food and Chemical Toxicology》在线发表CLARITY-BPA核心研究结果

发布日期:2019-07-29 13:36    来源:未知    浏览次数:52

继NTP2018年正式发布CLARITY-BPA核心研究报告后,CLARITY-BPA核心研究结果再次在《Food and Chemical Toxicology》在线发表。
摘要:
We report the data from the guideline-compliant two-year toxicology study conducted as part of the Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY-BPA). BPA (0, 2.5, 25, 250, 2,500, and 25,000 μg/kg body weight (bw)/day) was administered daily by gavage in 0.3% carboxymethylcellulose vehicle to NCTR Sprague-Dawley rats from gestation day 6 through the start of parturition and then directly to pups from the day after birth until postnatal day 21 (stop-dose arm) or continuously until termination at one or two years. The stop-dose arm was included to assess the potential for any BPA effects that were due to developmental exposure. No BPA-related effects were evident in the in-life and non-histopathology data. Neoplastic and nonneoplastic lesions diagnosed in both females and males were common age-associated lesions that were variable across control and BPA-treated groups. The lack of consistent responses within the continuous- and stop-dose arms within and across tissues brought into question the plausible relationship of most of these lesions to BPA treatment. There was a possible relationship between the increased incidences of lesions in the female reproductive tract and the male pituitary and exposure to the 25,000 μg BPA/kg bw/day dose level.

原文链接:
L.Camacho, et al. A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study result. Food and Chemical Toxicology, Available online 28 July 2019, 110728. https://doi.org/10.1016/j.fct.2019.110728


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