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2015年-无证据显示发育期暴露BPA会对啮齿类生殖器官产生生物学影响

发布日期:2018-11-05 11:29    来源:未知    浏览次数:143
Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats.

原文链接
   https://www.sciencedirect.com/science/article/pii/S0278691515001180?via%3Dihub

要点

1. The effects of seven “low BPA”, two “high BPA”, and two EE2 doses versus vehicle control were assessed at the molecular level.
2. Prostate and mammary glands, tissues previously identified as potential BPA targets, from Sprague-Dawley rats were analyzed.
3. Postnatal day 4 microarray data showed gene expression changes induced by “high BPA” overlapped par tially with those of EE2.

4. Genes were modulated also in “low BPA” dose range, but lack of dose response reduced likelihood these are treatment-related.
5. These results are consistent with the toxicity outcomes reported previously for this animal cohort.

 

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